I also find that ublock origin used to work (sort of) on previous versions but does not seem to work on this one.
I turned off content blockers as suggested, and the ublock origin interface appears to work better, and shows the matrix below too. however, on sites i visit, its not infested with ads.
before the update to the browser, which i did this morning, many of the ads i currently see were blocked with the combination of the browsers built in content blockers and ublock. now, for example, i am seeing cookie warnings, i am seeing "sign in with google" pop overs, etc.