I can confirm it's happening on my end too 
Here's me trying to download the orion browser dmg.
Edit:
Actually, just tried the solution shown here (re-selecting the download folder) and it seems to work now.
I would highly suggest to give an error message.
https://orionfeedback.org/d/3375-downloads-sometimes-fail-when-using-profiles
Honcharenko try re-selecting the download folder on your preferences.
I'm also experiencing this issue. Re-selecting my downloads folder did not fix my issue.
Steps to reproduce:
1.) Create a new profile that uses the initial profile created by defualt as a template
2.) Attempt to download a word document file or pdf(these are the only two I've attempted so far)
3.)download seems to start but immediately fails
Expected behavior:
Expected files to download and complete downloading as they would in the initial profile
Orion, OS version; hardware type:
Orion Ver. 0.99.122-beta
MacOS Monterey Ver. 12.6
Macbook Pro 2019 16 inch
laiz Can't confirm that. Issue still persists for me on Version 0.99.123.3-beta.
gitarero164 Can you show steps to reproduce/video?
Vlad I've done some more testing and it seems like the issue affects existing profiles aswell as new ones, and so far, only my Intel machine (macOS Monterey) - my Apple Silicon machine (macOS Ventura) does not seem to be affected by this whatsoever. I tested by lauching a profile (either existing or new, didnt matter) and downloading a test file (usually used speed.hetzner.de for this). Animation for starting the download appears, but the download immediately fails. Looks the same as it did before and was described and shown in previous posts.
Let me know if you still want a video of this, might have to censor some stuff I have open though, or share it privately in some way.
gitarero164 A video with steps to reproduce would be best.
