This bug is still present in Orion Version 0.99.125-rc (WebKit 616.1.22). It makes voice/video calling websites unusable for people with a custom microphone setup (virtual microphones are missing). For example, Discord voice settings page is laggy and beachballs in Orion. No other browsers (Safari, Firefox, Chromium) I tested have this problem.
Discord voice settings in Orion (40s clip):