I also started having problems when updating to Sequoia (non beta) when it was released. I have not found out how to reproduce it yet, but it happens several times every day. I also noticed that the extension for 1password sometimes "freezes" in the sense that the popup in the top right corner that says "Save in 1password"(or something similar) just stays there, blocking anything that might be underneath from interaction. A tab reload solves this. Will update if I find a way to reproduce. This is the most severe bug I have had in Orion so far, almost to the point of not usable.