This appears to only happen when launching the Orion Profile Session from the MacOS Dock or via Spotlight/Alfred/Etc.
To recreate: pin the Orion Profile 2 in your MacOS dock. Quit the Orion Profile 2 while keeping Profile 1 open. Open Profile 2 from the Dock or Open Profile Session 2 using App Launcher.
Note: if Profile 2 is closed. I am able to go to File > Profiles and select the Profile I want and it will launch correctly.