I just recorded a sample of a Twitch video played in both Safari and Orion, inverted one of them (which will cancel out any identical data, leaving only the difference), and played back the resulting audio. I can't hear anything besides some occasional little clicks (and the loudest of these is at -60dB, which wouldn't be audible, so must not be what you're talking about).
Is it possible you're playing back the video in Orion at something other than 1x speed...? That seems unlikely given that two people are both reporting this, but it's the only thing I can think of at the moment.
I am using exactly the same hardware and software as funkmaster-fl0w.