This one is very odd and very case-specific.
Steps to reproduce:
I use Lavarel Valet for local development https://laravel.com/docs/8.x/valet
Laravel Valet configures your Mac to always run Nginx in the background when your machine starts. Then, using DnsMasq, Valet proxies all requests on the *.test domain to point to sites installed on your local machine.
Valet can also secure local *test domain using a self-signed certificate.
When Valet is running in the background, Orion will randomly and often stop loading pages with the message "This connection is not private" clicking on the view certificate will show the " Laravel Valet CA Self Signed CN".
Turning off Valet fixed the issue immediately, and Orion will work again as expected.
Lavarel Valet should not interfere with Orion
Orion and macOS:
Orion: Version 0.99.108.1-beta (WebKit 613.1.10)
MacOS: 12.0.1 (21A559)
HW: MBP M1 Max