In Safari keyboard shortcuts will prioritize website itself if the cursor is inside the website/webapp.
For example, in a markdown webapp ⌥+⌘+1, 2, 3...were assigned for changing text headings,but it conflicts with the safari assigment to trigger top favorite sites. In this case Safari will respect the keyboard shortcuts in the webapps.
Would be nice to do this in Orion too, or have an option item to toggle.
Safari, Arc and Chrome seem to all prioritize keyboard shortcuts inside webapps when the cursor is inside the webapp.
This way user will have an option to where keyboard shortcut will apply.