Unlike Orion desktop, currently there doesn't appear to be any way to opt out of intelligent tracking protection or cross-site tracking protection on Orion mobile, whether in general or for specific sites. Extensions often need to make cross-site requests and this is highly likely the cause for my extension failing on the new Orion version (it was working as of version 1.3.8).
Having more control over the tracking protection settings can at least allow a smoother transition for extensions into stricter settings.
Users will continue to be able to use their extensions. They can decide when and where it's appropriate to turn tracking protection on or off.