Once Orion implements scriptlet support (called advanced js by them), like WebShield or wBlock does like Safari, YouTube ads will be blocked. Also you don't need optimized lists for Orion since I believe each list is a content blocker & advanced js is run in a js file not through content blocking.
The lists you should use could be the default lists in WebShield.
Off the top of my head, these should be enabled by default:
AdGuard Base
AdGuard Tracking
EasyPrivacy
I'm developing WebShield which is an adblocker for Safari, so if you have any questions regarding lists, please lmk. Respectfully, While @yokoffing's suggestions were better than just plain EasyList, Hagezi lists are meant primarily for DNS, have no cosmetic or especially scriptlet rules. You can get far better results by using the above lists as defaults. You don't need the optimized lists either I believe for the Orion implementation.