Steps to reproduce:
I have an installation on my local NAS of paperless-ngx, version 1.16.3. I can login to this installation (which runs just via HTTP in my local network) with Safari, but it does not work in Orion. I am always redirected to the login page without further info. The only cookie that gets set is a CSRF token; in Safari, login is successful and a sessionid cookie gets set.
Since this is a local install, I realise it will be hard for you to find out what's wrong -- any chance I can produce some useful debug info for you?
Orion, OS version; hardware type:
Version 0.99.124.3-beta (WebKit 616.1.14.11.1)
MacBook Pro (macOS Monterey 12.1 build 21C52) on 2019 MacBook Pro 13", Intel