I seem to have found at least one case where Orion does not successfully highlight the expected text but Chrome does:
https://docs.bluerobotics.com/ardusub-zola/software/autopilot/ArduSub-4.1/developers/mavlink-messages/#:~:text=MAVLink%20Dialect-,ADSB_VEHICLE,-GCS_MAVLink/GCS_Common.cpp

(Orion just goes to the start of the page, and doesn't highlight anything)
That said, I expect Orion's existing highlight+jump URL functionality is automatically available via WebKit, and that example also fails on Safari, so presumably the issue there is with the underlying WebKit implementation rather than an issue with Orion itself. Not sure if that kind of thing is best reported to Apple as a bug, and/or worked around in Orion in the meantime.