Are you trying to click on them on Orion's empty page?
The icons are not clickable there, you need to open a webpage so that they work. I made the same comments months ago, still think you should be able to open extension options without opening a page first.
For instance, if I want to open uBO to change a particular setting, why do I need to open a webpage first? If I don't have an internet connection I won't be able to do anything.