Now that we've had a least two reports in the rc channel, a bug report seems to be in order.

Steps to reproduce:
Generally the recipe for these issues has been the following:

Use a non-default profile
Put your Mac to sleep and resume
Downloads across all (non-default?) Orion profiles now fail (not 100% reproducible to my knowledge, still looking for a 100% reproducible recipe)
Fixing downloads requires either restarting the Orion process or manually changing the default download location to another location (and then switching back)

Expected behavior:
Downloading should not randomly break.
Orion, OS version; hardware type:
Version 0.99.120.1.3-rc (WebKit 614.1.20)
MacBook Air (macOS Monterey 12.6 build 21G115)
Image/Video: