Steps to reproduce:
Using the Firefox versions of Reddit Enhancement Suite and Stylus, when clicking a comment link from reddit, neither extension loads without a page reload.
Oddly, middle-clicking, or right click "Open in New Tab" where the tab doesn't focus immediately does work as expected and the page loads with the extensions working as expected.
Orion, OS version; hardware type:
Version 0.99.120.1-beta (WebKit 614.1.20)
iMac (macOS Monterey 12.5.1 build 21G83)