Steps to reproduce:
It's a critical shortcut that some websites just override for no reason at all.
It should always reload the page, regardless of any options.
Another alternative is to add permissions for a website to override any browser shortcuts at all.
This website above for example simply overrides the command key which shouldn't be possible. A malicious website can simply make windows and become fullscreen thus without command+W or command+R, or Q working, it can temporarily override the computer.