Logging into my Home Assistant instance reveals misaligned "cards" or "buttons" as we call them, but only on my personal profile - a fresh profile reveals that the UI aligns properly (much like my other bug around logging into our Discourse forums).
It does not happen in Safari nor on Orion's mobile app. Image below to show misalignment. All screenshots are taken from the same monitor to ensure the display resolutions are identical, and trying out compatibility mode doesn't affect it.

I expect the alignment of the UI to match the frontend, as seen below.
Safari

Clean profile in Orion

(Please let me know if you want to be connected to my colleagues - happy to make dev connections!)
Version 0.99.134-beta (WebKit 622.1.9.19.2)
Sequoia (15)