similar issue for me, but it's not just on large PRs.
basic actions in a repo like opening a dropdown menu - all extremely slow. 5-10s delay minimum before the page becomes interactive again, possibly several minutes or it just hangs forever.
on a large PR it breaks down to the point of becoming almost unusable. I've had to switch to using chrome to interact with github.
I just tested on Safari as well - no other open tabs, no history or anything, since I don't use Safari. It's fairly slow; not as bad as it's been in Orion, but definitely not snappy like it is on chrome.
...it's astonishing how bad it is - but I assume it's Microsoft shenanigans, as I've seen catastrophic slowdown in VSCode with the Copilot extension enabled (copy and paste a line could take 10s), and Copilot is totally intertwined with GH now.
I'd gotten a little bit of reprieve after restarting my system entirely and reopening my last window, but that's not guaranteed and it doesn't last long.