EDIT: Exactly one year has passed! Didn't notice it at first. That makes this thread even more important and puzzling.
There are over 300,000 extensions out there and we are not initimately famiiliar with how they work.
Vlad Then maybe focus on the few who are the most popular in the world? uBlock Origin is not "one of those 300,000 extensions", it is hands down the best content blocker on the market today, especially considering what Youtube dared to do to users by late 2023.
As for me, I use AdNauseam (the Firefox extension). It is also based on uBlock Origin. I use AdNauseam because I find it prettier and easier to configure, but that is a matter of taste. I can confirm that the Google Translate extension from the Chrome web store does not work when both are installed. And Google Translate is not "one of those 300,000 extensions" either, especially as Orion lacks the built-in ability of Safari to translate web pages.
uBlock Origin (and its variant AdNauseam) do not prevent Google Translate from working in other browsers.
PS: The combination of the "Safari look & feel" + AdNauseam extension (against YouTube horrific ads) is primarily the reason that led me to install Orion on my iMac, iPad and iPhone in the first place, and configured it as the default web browser instead of Safari.